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Oregon grape root is a tall, evergreen, flowering shrub that grows among the firs, spruces, and pines of the mountainous American Northwest. The state flower of Oregon, Oregon grape root bears fruit but "grapes" is an inaccurate description. Oregon grape root is a useful substitute for goldenseal, which has been over harvested in the wild. It is not as fussy about its habitat than the closely related barberry, and easier to find. As a purely bitter herb, Oregon grape root is used easily with Traditional Chinese Medicine, having the same function and only a little less potency than coptis.

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Oregon Grape has been used for hundreds of years because of its powerful antibiotic properties and has been extensively examined as an effective herb for various skin conditions.

Oregon Grape herb is a quickly-growing shrub about 6 feet high: the oddly compound leaves have no spine at the base; they are evergreen and shining. The flowers grow in terminal racemes, are small and yellowish-green in colour, and the purple berries are three- to nine-seeded. The bark is brown on the surface and yellow beneath. The root is from 1/2 inch in diameter to 3 inches at the base of the stem, odourless, and with a bitter taste. The shrub was introduced into England from North America in 1823. It was formerly known as Mahonia aquifolia and is very hardy.