History Of DHEA!

It is in 1931 that Dr. Adolf BUTERNANDT, a German fellow, isolates DHEA in its free form, in human urine. This doctor obtained the Nobel Prize for chemistry a few years later, in 1939. In 1944, the sulphated form of DHEA is isolated DHEA-S.

It is only 20 years later, in 1954, that two researchers, Migeon and Plager, isolate DHEA in human blood, and precise histological studies indicate that it is produced by the internal part of the suprarenal cortex.

In 1958, the French man Max Fernand JAYLE, professor of biochemistry at the Faculty of Medicine of Paris, manages to proportion precisely the quasi linear decrease of DHEA in men and women progressively with aging.

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Professor Etienne-Emile Baulieu's research on a case of human suprarenal tumor in 1960, brings the proof that DHEA was well synthesized by the suprarenal glands, but in the form of dehydroepiandrosterone sulphate DHEA-S.

In men, the metabolism of DHEA and DHEA-S was particularly studied during the 1960s, by oral administration or intravenous injection. Thus, the transformation of DHEA into DHEA-S and the metabolism of DHEA in androgens and estrogens was confirmed. It was significant to show that the metabolism of DHEA-S involves the formation of the same derivatives as DHEA itself.

In the 1970s, a series of international studies showed the possibility for beneficial effects of DHEA on animals. These many works were undertaken on laboratory animals (rats and mice especially), studying the effects of the administration of DHEA generally mixed with food.

At the Broussais Hospital in Paris, Professors Jayle and Kazatchkine gave 100 mg/day for 4 months to seropositive subjects with the AIDS virus. No toxic effects have been noted to date. The results are still not published. It was also noted that DHEA increases sensitivity to thyroid hormones, improving the thermo genesis, the metabolism of slightly fat individuals, and energy production.

In April 2000, Professor Baulieu publishes the results of the study "DHEAGE" which studies 280 volunteers over 60 years old taking 50 mg of DHEA per day during one year. The results are proven and are positive for the women. It is probable that men require stronger amounts (75 to100mg per day).

In November 2000: crucial turn. The French Medical Authorities authorize the sale of DHEA. However DHEA still does not have a MA (Marketing Authorization) in France, but, thanks to a gap in the law, it can be sold in pharmacy, in the form of masterly preparation.



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