History Of Carnitine

The carnitine story began in 1964, when a major American drug company encouraged me to take a fellowship in clinical phammacology at St. Vincent's Medical Center in New York City. At that time, a French phammaceutical company had asked the American company whether it had any interest in the possible antihyperthyroid activity of carnitine. Since thyroid disease was one area of my expertise, they asked me to evaluate carnitine in hyperthyroidism. Three patients with classic hyperthyroidism were chosen for the initial study. During the first week of carnitine administration, all three became clinically euthyroid, and there was a concomitant fall in pulse rate-a remarkable achievement in this patient population. Surprisingly, thyroid function tests were unchanged, indicating that carnitine was not acting on the thyroid gland but was acting peripherally.

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We submitted the results of the study to a few journals, but the report was rejected for publication because only a subjective observation confirmed that a therapeutic event had occurred. With the impatience of youth, We became angry, arguing that even an effective antigravity pill could not be proven to the satisfaction of the Journal of the American Medical Association unless the upward distance traveled by the volunteer was precisely measured. The subjective observation that he, like Elijah, was rocketing toward heaven would not be sufficient for publication. The effort having proved futile, We went on to the next logical step, a clinical trial to obtain objective data. The American company had established a sophisticated clinical research unit in a prison, and there, after administering thyroid hormone (triiodothyronine) to volunteers, we measured whether carnitine would alter the effects of exogenous thyroid hormone on blood lipids and other parameters. Carnitine did alter certain effects. We published both the subjective and the objective data, but, strangely, endocrinologists still have not recognized these studies,



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